Open Journal Article: Migraine pathogenesis and state of pharmacological treatment options (Link Corrected)

2009 November 16


Migraine is a largely inherited disorder of the brain characterised by a complex but stereotypical dysfunction of sensory processing. The most obvious clinical symptom often is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presentation. This review discusses current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. Acute and preventive migraine treatment approaches are briefly covered with a focus on shortcomings of the currently available treatment options. A number of different receptors such as calcitonin gene-related peptide (CGRP), TRPV1 and glutamate receptors are currently being targeted by potential novel migraine therapeutics. Prospects of this research are exciting and likely to improve the patient care.

You can read the full article here: http://www.biomedcentral.com/content/pdf/1741-7015-7-71.pdf


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